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Lady Gaga apparently wants David Letterman to be her “G.U.Y.

Mother Monster will take over the “Late Show” on Wednesday, marking her first performance on the late night talker.

According to the official CBS press release, Gaga will make a “special musical performance” to promote her residency at the Roseland Ballroom in New York before the venue’s closure.

There’s a good change Gaga, who is also set to tour behind her latest LP, “Artpop,” will perform her latest single, “G.U.Y.” The much-hyped music video has garnered more than 26 million hits on Youtube in just over a week.

Yet this is not the first time the pop star has appeared on Letterman’s show, last time sitting down with the host.

After Dave listed up a series of rumors about the star on her May 2011 appearance, she tore up the paper and took a bite.

Watch a clip from Gaga’s last appearance on the “Late Show” and sound off on tonight’s performance in the comments!