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It’s no secret that Grey Sloane Memorial Hospital is a revolving door – just look at how many names the hospital itself has had.

That reputation isn’t going away anytime soon, what with the news that two other series regulars will depart the show at the end of the season along with the previously-announced Sandra Oh.

According to “The Hollywood Reporter,” Tessa Ferrer’s Leah and Gaius Charles’s Shane will also exit at the end of season 10, as their contracts have not been picked up for the likely 11th season.

Five interns were introduced last season, including Tina Majorino’s dearly departed Brooks, while Camilla Luddington’s Jo and Jerrika Hinton’s Stephanie joined the outgoing duo as cast members this season.

It’s not clear at this time whether this marks all of the cast departures, though Patrick Dempsey and Ellen Pompeo are contracted for two more seasons.

Will you be sad to see Leah and Shane go? Let us know in the comments!